Two sample MR report
KANSL1-AS1_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 67 | 0.0233279 | 0.0128976 | 0.0751218 |
| Weighted median | 67 | 0.0196458 | 0.0024653 | 0.0000000 |
| Inverse variance weighted | 67 | 0.0176881 | 0.0019045 | 0.0000000 |
| Simple mode | 67 | 0.0201639 | 0.0052916 | 0.0003070 |
| Weighted mode | 67 | 0.0200378 | 0.0052308 | 0.0002872 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 25.16083 | 65 | 0.9999980 |
| Inverse variance weighted | 25.35630 | 66 | 0.9999986 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0052346 | 0.0118398 | 0.6598682 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0027088 | 0 | TRUE | 7e-07 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
